Similarly, the UBR2 Polyclonal Antibody (PACO37610) is a valuable tool for researchers studying the UBR2 protein. UBR2 is a ubiquitin ligase that plays a role in protein degradation, cell cycle regulation, and DNA repair processes. The antibody, produced in rabbits, exhibits high specificity for human samples and is suitable for Western blotting applications.By targeting the UBR2 protein, this antibody allows for the detection and analysis of UBR2 expression in various cell types, providing insights into its function and potential implications in cancer biology, cell signaling pathways, and beyond.
Researchers can utilize this antibody to explore the role of UBR2 in cellular processes and potentially uncover new therapeutic targets for various diseases.
Antibody Name:
UBR2 Antibody (PACO37610)
Antibody SKU:
PACO37610
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human, Mouse
Immunogen:
Recombinant Human E3 ubiquitin-protein ligase UBR2 protein (101-439AA)
Western Blot. All lanes: UBR2 antibody at 3µg/ml + Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 201, 50, 67 kDa. Observed band size: 201 kDa.
Background:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
UBR2: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Belongs to the UBR1 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Ligase; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 6p21.1Cellular Component: nucleoplasm; plasma membrane; chromatin; ubiquitin ligase complexMolecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activityBiological Process: ubiquitin-dependent protein catabolic process; negative regulation of TOR signaling pathway; male meiosis I; chromatin silencing; spermatogenesis; histone H2A ubiquitination
UniProt Protein Details:
NCBI Summary:
This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
