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UBR1 Antibody (PACO01674)

SKU:
PACO01674
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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UBR1 Antibody (PACO01674)

The UBR1 Polyclonal Antibody (PACO01674) is a valuable tool for researchers studying the UBR1 protein, which is involved in the ubiquitin-proteasome system. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications.UBR1 plays a crucial role in protein degradation and turnover within cells, making it essential for maintaining cellular homeostasis. Dysregulation of the ubiquitin-proteasome system has been implicated in various diseases, including cancer and neurodegenerative disorders.

By targeting UBR1 with this antibody, researchers can gain insights into its function and potential therapeutic implications.With its specificity and reliability, the UBR1 Polyclonal Antibody is a valuable tool for scientists conducting research in cell biology, molecular biology, and disease mechanisms related to protein degradation pathways. Its ability to detect UBR1 protein in various cell types makes it an essential component for studies aimed at understanding the role of UBR1 in health and disease.

Antibody Name:UBR1 Antibody
Antibody SKU:PACO01674
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human Ubr1.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:UBR1; E3 ubiquitin-protein ligase UBR1; N-recognin-1; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I
UniProt Protein Function:UBR1: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Defects in UBR1 are a cause of Johanson-Blizzard syndrome (JBS). This disorder includes congenital exocrine pancreatic insufficiency, multiple malformations such as nasal wing aplasia, and frequent mental retardation. Pancreas of individuals with JBS do not express UBR1 and show intrauterine- onset destructive pancreatitis. Belongs to the UBR1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin ligase; Ligase; EC 6.3.2.19; EC 6.3.2.-; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 15q13

Cellular Component: cytoplasm; cytosol; proteasome complex; ubiquitin ligase complex

Molecular Function:ligase activity; zinc ion binding

Biological Process: negative regulation of TOR signaling pathway; protein ubiquitination

Disease: Johanson-blizzard Syndrome

NCBI Summary:The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:Q8IWV7
NCBI GenInfo Identifier:73622071
NCBI Gene ID:197131
NCBI Accession:Q8IWV7.1
UniProt Secondary Accession:Q8IWV7,O60708, O75492, Q14D45, Q68DN9, Q8IWY6, Q96JY4
UniProt Related Accession:Q8IWV7
Molecular Weight:93,184 Da
NCBI Full Name:E3 ubiquitin-protein ligase UBR1
NCBI Synonym Full Names:ubiquitin protein ligase E3 component n-recognin 1
NCBI Official Symbol:UBR1  
NCBI Official Synonym Symbols:JBS  
NCBI Protein Information:E3 ubiquitin-protein ligase UBR1
UniProt Protein Name:E3 ubiquitin-protein ligase UBR1
UniProt Synonym Protein Names:N-recognin-1; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:UBR1  
UniProt Entry Name:UBR1_HUMAN

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