The UBQLN4 Polyclonal Antibody (CAB15869) is a valuable tool for researchers studying UBQLN4, a protein involved in protein degradation pathways and cellular homeostasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the UBQLN4 protein, this antibody allows for the detection and analysis of UBQLN4 in various cell types, making it an excellent choice for studies in molecular biology, cell biology, and neurodegenerative diseases.UBQLN4, also known as ubiquilin-4, is a key player in the ubiquitin-proteasome system, which is responsible for the targeted degradation of proteins within cells. Dysregulation of this system has been implicated in various diseases, including neurodegenerative disorders such as Alzheimer's and Parkinson's disease.
By understanding the role of UBQLN4 in protein quality control mechanisms, researchers can gain insights into the pathogenesis of these conditions and potentially identify new therapeutic targets.Overall, the UBQLN4 Polyclonal Antibody (CAB15869) is a valuable tool for researchers investigating the function and regulation of UBQLN4 in physiological and pathological conditions. Its high specificity and sensitivity make it an essential reagent for studies aiming to unravel the complex mechanisms of protein degradation and cellular stress responses.
Product Name:
UBQLN4 Rabbit Polyclonal Antibody
SKU:
CAB15869
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 366-432 of human UBQLN4 (NP_064516.2).
Enables K48-linked polyubiquitin modification-dependent protein binding activity and identical protein binding activity. Involved in cellular response to DNA damage stimulus; negative regulation of double-strand break repair via homologous recombination; and regulation of cellular catabolic process. Located in several cellular components, including autophagosome; nucleoplasm; and site of DNA damage. Part of protein-containing complex. Colocalizes with cytosolic proteasome complex and nuclear proteasome complex.
Purification Method:
Affinity purification
Gene ID:
56893
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using UBQLN4 Rabbit pAb (CAB15869) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
