The UBQLN3 Polyclonal Antibody (CAB17697) is a critical tool for researchers studying UBQLN3, a protein involved in the ubiquitin-proteasome system, which plays a key role in protein degradation and quality control. This rabbit-derived antibody has high specificity and sensitivity for UBQLN3 in human samples, making it ideal for use in Western blotting and other immunological studies.UBQLN3 is known to interact with various proteins involved in protein degradation pathways, making it a potential target for research into neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.
By targeting UBQLN3, researchers can gain valuable insights into the mechanisms underlying protein aggregation and clearance, which are fundamental processes in the development of these disorders.With its ability to specifically detect UBQLN3 in a variety of cell types, the CAB17697 antibody is a valuable tool for researchers aiming to understand the role of UBQLN3 in disease pathology and explore potential therapeutic interventions. Its high reactivity and validation for Western blot applications make it a reliable choice for studies in neuroscience, molecular biology, and beyond.
Product Name:
UBQLN3 Rabbit Polyclonal Antibody
SKU:
CAB17697
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 306-620 of human UBQLN3 (NP_059509.1).
This gene encodes a ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and are thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis. It has been suggested that this gene may regulate cell-cycle progression during spermatogenesis, however, it has been shown that the ortholgous mouse gene is dispensable for embryonic development and spermatogenesis.
Purification Method:
Affinity purification
Gene ID:
50613
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UBQLN3 Rabbit pAb (CAB17697) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
