The UBL5 Polyclonal Antibody (CAB18481) is a valuable tool for researchers studying the UBL5 protein, a key player in various cellular processes such as protein degradation, intracellular trafficking, and DNA repair. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been rigorously validated for use in Western blot applications. By binding specifically to UBL5, it allows for the precise and reliable detection and analysis of this protein in different cell types, making it an essential component for investigations in molecular biology and cancer research.
UBL5, also known as ubiquitin-like 5, is an essential component of the ubiquitin-proteasome system, which plays a crucial role in maintaining cellular homeostasis by degrading damaged or unnecessary proteins. Dysregulation of UBL5 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. By unraveling the functions and mechanisms of UBL5, researchers can gain valuable insights into disease processes and potentially identify novel therapeutic targets for intervention.
Product Name:
UBL5 Polyclonal Antibody
SKU:
CAB18481
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-73 of human UBL5 (NP_077268.1).
This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Purification Method:
Affinity purification
Gene ID:
59286
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using UBL5 Rabbit pAb (CAB18481) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
