The UBL4B Polyclonal Antibody (PAC017358) offered by Assay Genie is a valuable tool for researchers investigating UBL4B, a protein involved in ubiquitin-like protein conjugation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By targeting the UBL4B protein, researchers can accurately detect and study its expression in various cell types, making it ideal for studies in molecular biology and cellular signaling pathways.
UBL4B is known to play a crucial role in cellular processes such as protein degradation and DNA repair, making it a key player in maintaining cellular homeostasis. Research on UBL4B is important for understanding its involvement in diseases like cancer, neurodegenerative disorders, and metabolic diseases. By studying UBL4B activity, researchers can uncover potential therapeutic targets for these conditions, ultimately leading to the development of novel treatment strategies.
Antibody Name:
UBL4B Antibody (PACO17358)
Antibody SKU:
PACO17358
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human
Immunogen:
Full length fusion protein
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO17358(UBL4B Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Ubiquitin is a 77 amino acid, protein that targets proteins for degradation by the 26S proteasome. Ubiquitin-like proteins are not directly involved in protein degradation, but appear to have many mechanistic similarities with the ubiquitin pathway. UBL4B (Ubiquitin-like protein 4B) is a 174 amino acid, cytoplasmic protein that contains a ubiquitin-like domain. UBL4B likely arose by retroposition during mammalian evolution from UBL4A, an X-linked intron-bearing housekeeping gene. While UBL4A is highly conserved, UBL4B has undergone rapid evolution and may have evolved new functions. Expression of UBL4B is restricted to post-meiotic germ cells in testis and ovarian tissue, where it likely functions in post-translational protein modification.
Synonyms:
ubiquitin-like 4B
UniProt Protein Function:
UBL4B: Protein type: Ubiquitin-like modifierChromosomal Location of Human Ortholog: 1p13.3Molecular Function: protein binding
