The UBL4B Polyclonal Antibody (PAC017357) is a valuable tool for researchers studying UBL4B, a key protein involved in various cellular processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the UBL4B protein, this antibody enables accurate detection and analysis in a wide range of cell types, making it ideal for research in molecular biology and cell signaling pathways.UBL4B is known for its role in the ubiquitin-proteasome system, a crucial pathway for protein degradation and regulation.
Dysregulation of this system has been implicated in various diseases, including cancer and neurodegenerative disorders. By studying UBL4B and its interactions, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets. The UBL4B Polyclonal Antibody is a powerful tool for advancing knowledge in these areas and driving forward scientific discoveries.
Antibody Name:
UBL4B Antibody (PACO17357)
Antibody SKU:
PACO17357
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Full length fusion protein
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17357(UBL4B Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17357(UBL4B Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Ubiquitin is a 77 amino acid, protein that targets proteins for degradation by the 26S proteasome. Ubiquitin-like proteins are not directly involved in protein degradation, but appear to have many mechanistic similarities with the ubiquitin pathway. UBL4B (Ubiquitin-like protein 4B) is a 174 amino acid, cytoplasmic protein that contains a ubiquitin-like domain. UBL4B likely arose by retroposition during mammalian evolution from UBL4A, an X-linked intron-bearing housekeeping gene. While UBL4A is highly conserved, UBL4B has undergone rapid evolution and may have evolved new functions. Expression of UBL4B is restricted to post-meiotic germ cells in testis and ovarian tissue, where it likely functions in post-translational protein modification.
Synonyms:
ubiquitin-like 4B
UniProt Protein Function:
UBL4B: Protein type: Ubiquitin-like modifierChromosomal Location of Human Ortholog: 1p13.3Molecular Function: protein binding
