The Ubiquilin-2 Polyclonal Antibody (CAB9568) is a valuable tool for researchers studying Ubiquilin-2, a protein involved in the regulation of protein degradation pathways. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to Ubiquilin-2, this antibody allows for the detection and analysis of this protein in various cell types, facilitating research in areas such as neurodegenerative diseases, cancer, and protein aggregation disorders.
Ubiquilin-2 plays a critical role in the clearance of misfolded and aggregated proteins, making it a key player in maintaining cellular homeostasis. Dysregulation of Ubiquilin-2 has been implicated in various diseases, highlighting the importance of understanding its function and regulation. By studying Ubiquilin-2 using this antibody, researchers can gain insight into the mechanisms underlying protein degradation pathways and potentially identify new therapeutic targets for disease intervention.
Product Name:
UBQLN2 Rabbit Polyclonal Antibody
SKU:
CAB9568
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human UBQLN2 (NP_038472.2).
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.
Purification Method:
Affinity purification
Gene ID:
29978
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using UBQLN2 Rabbit pAb (CAB9568) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
