The UBE4B Polyclonal Antibody (CAB17609) is a valuable tool for researchers studying the role of UBE4B, a protein involved in the ubiquitination pathway and protein degradation. This rabbit polyclonal antibody is highly specific for human samples and has been validated for use in Western blot applications.UBE4B plays a crucial role in maintaining cellular homeostasis by targeting proteins for degradation through the ubiquitin-proteasome system. Dysregulation of UBE4B has been implicated in various diseases, including cancer and neurodegenerative disorders.
By targeting UBE4B, researchers can gain insights into the mechanisms underlying these diseases and potentially develop targeted therapies.The UBE4B Polyclonal Antibody enables the detection and analysis of UBE4B in different cell types, making it a versatile tool for studies in molecular biology and disease research. Its high specificity and sensitivity make it an ideal choice for researchers investigating the functions of UBE4B and its potential as a therapeutic target.
Product Name:
UBE4B Rabbit Polyclonal Antibody
SKU:
CAB17609
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 130-250 of human UBE4B (NP_006039.2).
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10277
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UBE4B Rabbit pAb (CAB17609) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
