The UBE4A Polyclonal Antibody (CAB3354) is a valuable tool for researchers studying UBE4A, a protein involved in the ubiquitin-proteasome system which plays a critical role in protein degradation and turnover. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the UBE4A protein, this antibody enables precise detection and analysis in various cell types, making it ideal for studies in molecular biology and disease mechanisms.UBE4A is known for its function in targeting misfolded proteins for degradation, a process crucial for maintaining cellular homeostasis and preventing the accumulation of damaged proteins.
Dysregulation of the ubiquitin-proteasome system, including UBE4A dysfunction, has been implicated in various diseases such as neurodegenerative disorders and cancer. Investigating the role of UBE4A with the help of this antibody can provide valuable insights into disease pathways and potential therapeutic targets.Overall, the UBE4A Polyclonal Antibody is a reliable tool for researchers interested in studying the function of UBE4A in cellular processes and disease pathogenesis. Its specificity and sensitivity make it a valuable asset for advancing research in the fields of molecular biology, neurobiology, and cancer biology.
Product Name:
UBE4A Rabbit Polyclonal Antibody
SKU:
CAB3354
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 797-1066 of human UBE4A (NP_001191006.1).
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
9354
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using UBE4A Rabbit pAb (CAB3354) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
