UniProt Protein Function: | UBE3B: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Ligase; EC 6.3.2.19; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 12q24.11Molecular Function: ligase activity; ubiquitin-protein ligase activityBiological Process: protein ubiquitination during ubiquitin-dependent protein catabolic processDisease: Kaufman Oculocerebrofacial Syndrome |
UniProt Protein Details: | |
NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012] |
UniProt Code: | Q7Z3V4 |
NCBI GenInfo Identifier: | 296453010 |
NCBI Gene ID: | 89910 |
NCBI Accession: | Q7Z3V4.3 |
UniProt Secondary Accession: | Q7Z3V4,Q05BX9, Q659F7, Q7Z7Q1, Q9BXZ4, A5D8Z3 |
UniProt Related Accession: | Q7Z3V4 |
Molecular Weight: | |
NCBI Full Name: | Ubiquitin-protein ligase E3B |
NCBI Synonym Full Names: | ubiquitin protein ligase E3B |
NCBI Official Symbol: | UBE3BÂ Â |
NCBI Official Synonym Symbols: | KOS; BPIDSÂ Â |
NCBI Protein Information: | ubiquitin-protein ligase E3B |
UniProt Protein Name: | Ubiquitin-protein ligase E3B |
UniProt Synonym Protein Names: | |
Protein Family: | Ubiquitin-protein ligase |
UniProt Gene Name: | UBE3BÂ Â |
UniProt Entry Name: | UBE3B_HUMAN |