UBE3A Rabbit Polyclonal Antibody (CAB1757)
- SKU:
- CAB1757
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | UBE3A Rabbit Polyclonal Antibody |
SKU: | CAB1757 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-590 of human UBE3A (NP_570853.1). |
Sequence: | KLIR LWSK YNAD QIRR MMET FQQL ITYK VISN EFNS RNLV NDDD AIVA ASKC LKMV YYAN VVGG EVDT NHNE EDDE EPIP ESSE LTLQ ELLG EERR NKKG PRVD PLET ELGV KTLD CRKP LIPF EEFI NEPL NEVL EMDK DYTF FKVE TENK FSFM TCPF ILNA VTKN LGLY YDNR IRMY SERR ITVL YSLV QGQQ LNPY LRLK VRRD HIID DALV RLEM IAME NPAD LKKQ LYVE FEGE QGVD EGGV SKEF FQLV VEEI FNPD IGMF TYDE STKL FWFN PSSF ETEG QFT |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | AS; ANCR; PIX1; E6-AP; HPVE6A; EPVE6AP; UBE3A |
Positive Sample: | HeLa,K-562,293F |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 101kDa |
Observed MW: | 100kDa |
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
Purification Method: | Affinity purification |
Gene ID: | 7337 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |