The UBE2V1 Polyclonal Antibody (CAB6316) is a valuable tool for researchers studying the UBE2V1 protein, a key component of the ubiquitination process. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in Western blot applications. By targeting the UBE2V1 protein, this antibody enables accurate detection and analysis in various cell types, aiding in research related to protein degradation, cellular signaling, and disease mechanisms.UBE2V1, also known as ubiquitin-conjugating enzyme E2 variant 1, plays a crucial role in mediating the transfer of ubiquitin to target proteins, marking them for degradation by the proteasome.
Dysregulation of the ubiquitination process has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions. Therefore, understanding the function of UBE2V1 is essential for uncovering new therapeutic targets and developing treatments for these diseases.Overall, the UBE2V1 Polyclonal Antibody (CAB6316) offers a reliable tool for researchers investigating the role of UBE2V1 in cellular processes and disease pathways. Its specificity, sensitivity, and validated performance in Western blot experiments make it a valuable asset for advancing our understanding of ubiquitination and its implications in health and disease.
Product Name:
UBE2V1 Rabbit Polyclonal Antibody
SKU:
CAB6316
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human UBE2V1 (NP_001027459.1).
Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
Purification Method:
Affinity purification
Gene ID:
7335
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UBE2V1 antibody (CAB6316) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
