UBE2S Monoclonal Antibody [PAT2N6AT] (CPAB0153)
- SKU:
- CPAB0153
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG2a
- Clone:
- PAT2N6AT
- Applications:
- WB
- IF
- ELISA
Description
UBE2S Monoclonal Antibody [PAT2N6AT] (CPAB0153)
The UBE2S Polyclonal Antibody (CPAB0153) is a valuable tool for researchers studying UBE2S, a key enzyme involved in the ubiquitination pathway. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the UBE2S protein, this antibody enables the detection and analysis of UBE2S in different cell types, making it ideal for studies in protein degradation, cell cycle regulation, and DNA repair mechanisms.
UBE2S, also known as ubiquitin-conjugating enzyme E2S, plays a crucial role in the ubiquitin-proteasome system, which regulates protein turnover and degradation. Dysregulation of this pathway has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions. By understanding the function of UBE2S, researchers can gain insight into the mechanisms underlying disease pathology and potentially identify new therapeutic targets for intervention.
| Product Name: | UBE2S Antibody |
| Product Sku: | CPAB0153 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human UBE2S mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human UBE2S amino acids 1-222 purified from Ecoli. |
| Clone: | PAT2N6AT. |
| Reactivity: | Human |
| Applications: | Western Blot, Immunofluorescence, ELISA |
| Purification Method: | UBE2S antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG2a |
| Background: | Ubiquitin-conjugating enzyme E2S (UBE2S) belongs to the ubiquitin-conjugating enzyme family. UBE2S is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a typical property of ubiquitin carrier proteins. UBE2S catalyzes the covalent attachment of ubiquitin to other proteins. UBE2S acts as a crucial factor of the anaphase promoting complex/cyclosome (APC/C), which is a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. UBE2S acts by purposely elongating ''Lys-11''-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, augmenting the degradation of APC/C substrates by the proteasome and promoting mitotic exit. UBE2S also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is nevertheless uncertain whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. UBE2S is also involved in ubiquitination and consequent degradation of VHL, resu |
| Synonyms: | Ubiquitin-conjugating enzyme E2 S, Ubiquitin-protein ligase S, Ubiquitin carrier protein S, Ubiquitin-conjugating enzyme E2-24 kDa, E2-EPF5, E2-EPF, UBE2S, E2EPF, EPF5. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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