The UBE2R2 Polyclonal Antibody (CAB7373) is a valuable tool for researchers studying the UBE2R2 protein, a key player in the ubiquitination pathway. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By targeting the UBE2R2 protein, this antibody enables precise detection and analysis in a variety of cell types, facilitating studies in cell biology, protein degradation, and disease mechanisms.UBE2R2, also known as ubiquitin-conjugating enzyme E2R2, is involved in the transfer of ubiquitin molecules to target proteins, marking them for degradation by the proteasome.
Dysregulation of the ubiquitination pathway has been linked to various diseases, including cancer, neurodegenerative disorders, and immune dysfunction. By investigating the role of UBE2R2 in these processes, researchers can gain valuable insights into potential therapeutic targets and treatment strategies.Overall, the UBE2R2 Polyclonal Antibody (CAB7373) serves as a powerful tool for studying the ubiquitination pathway and its implications in disease development. Its reliability and specificity make it a valuable asset for researchers seeking to unravel the intricate mechanisms underlying cellular homeostasis and disease progression.
Product Name:
UBE2R2 Rabbit Polyclonal Antibody
SKU:
CAB7373
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-238 of human UBE2R2 (NP_060281.2).
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation.
Purification Method:
Affinity purification
Gene ID:
54926
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UBE2R2 antibody (CAB7373) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
