The UBE2O Polyclonal Antibody (CAB17201) is a valuable tool for researchers studying UBE2O, a ubiquitin-conjugating enzyme involved in protein degradation and regulation. Raised in rabbits, this antibody exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the UBE2O protein, researchers can accurately detect and analyze its expression in various cell types, making it an ideal choice for studies in cell biology, ubiquitination pathways, and cancer research.
UBE2O plays a crucial role in maintaining protein homeostasis by tagging proteins for degradation through the ubiquitin-proteasome system. Dysregulation of UBE2O has been linked to various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions. By investigating the function and expression of UBE2O, researchers can gain insights into the underlying mechanisms of these diseases and potentially identify new therapeutic targets for intervention.
Product Name:
UBE2O Rabbit Polyclonal Antibody
SKU:
CAB17201
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1073-1292 of human UBE2O (NP_071349.3).
Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase activity. Involved in positive regulation of BMP signaling pathway; protein ubiquitination; and retrograde transport, endosome to Golgi. Located in cytoplasm and nuclear body.
Purification Method:
Affinity purification
Gene ID:
63893
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma using UBE2O Rabbit pAb (CAB17201) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
