The UBE2NL Polyclonal Antibody (CAB8381) is specifically designed for research involving UBE2NL, a ubiquitin-conjugating enzyme known for its role in protein degradation and regulation. Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the UBE2NL protein, this antibody enables detection and analysis in various cell types, making it an ideal tool for studies in molecular biology, cell signaling, and protein degradation pathways.UBE2NL is a crucial component in the ubiquitin-proteasome system, which controls the degradation of damaged or unwanted proteins in the cell.
Dysregulation of this system has been linked to various diseases, including cancer, neurodegenerative disorders, and immune-related conditions. Research into the function of UBE2NL is therefore essential for understanding these diseases and developing targeted therapies to treat them.Overall, the UBE2NL Polyclonal Antibody (CAB8381) provides researchers with a valuable tool for investigating the role of UBE2NL in cellular processes and disease pathways. Its high reactivity and specificity make it an excellent choice for studies aimed at unraveling the complexities of protein degradation and its implications for human health.
Product Name:
UBE2NL Rabbit Polyclonal Antibody
SKU:
CAB8381
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human UBE2NL (NP_001013007.1).
This gene is intronless and encodes a member of the ubiquitin-conjugating enzyme family. The protein product is 91% identical to ubiquitin-conjugating enzyme E2N, a multi-exon gene product. This locus represents a polymorphic pseudogene, where some individuals contain an allele that can encode a full-length protein, while others have a non-functional allele containing a premature stop codon (reference SNP rs237520) that truncates the coding sequence.
Purification Method:
Affinity purification
Gene ID:
389898
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UBE2NL antibody (CAB8381) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
