The UBE2L6 Polyclonal Antibody (CAB4282) is a valuable tool for research involving UBE2L6, a protein involved in the ubiquitination pathway, specifically targeting substrates involved in cell cycle regulation and DNA repair. The antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the UBE2L6 protein, this antibody enables the detection and analysis of UBE2L6 levels in various cell types, making it ideal for studies in molecular biology and cancer research.UBE2L6, also known as ubiquitin-conjugating enzyme E2 L6, plays a crucial role in the ubiquitination process by transferring ubiquitin molecules to substrate proteins, marking them for degradation or signaling purposes.
Its involvement in cell cycle control and DNA damage response makes it a key player in maintaining genomic stability and regulating cell proliferation. Research on UBE2L6 function is essential for understanding the mechanisms underlying cellular processes and diseases such as cancer, neurodegenerative disorders, and genetic syndromes. Through in-depth studies utilizing the UBE2L6 Polyclonal Antibody, researchers can unravel the complexities of UBE2L6-mediated pathways and potentially discover new therapeutic targets for various human conditions.
Product Name:
UBE2L6 Rabbit Polyclonal Antibody
SKU:
CAB4282
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-153 of human UBE2L6 (NP_004214.1).
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9246
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse spleen, using UBE2L6 Rabbit pAb (CAB4282) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
