The UBE2L6 Polyclonal Antibody (CAB13670) is a vital tool for researchers studying UBE2L6, a protein involved in the ubiquitination pathway essential for protein degradation and cellular regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to UBE2L6, it enables precise detection and analysis in various cell types, making it an ideal choice for studies in molecular biology and cellular pathways.
UBE2L6, also known as ubiquitin-conjugating enzyme E2L6, plays a crucial role in protein turnover and cellular homeostasis by tagging proteins for degradation. Dysregulation of UBE2L6 function has been linked to various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. Investigating the function and regulation of UBE2L6 is essential for understanding its role in disease pathology and developing potential therapeutic interventions that target the ubiquitination process.
Product Name:
UBE2L6 Rabbit Polyclonal Antibody
SKU:
CAB13670
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-153 of human UBE2L6 (NP_004214.1).
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9246
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using UBE2L6 antibody (CAB13670) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
