The UBE2K Polyclonal Antibody (CAB1086) is a valuable tool for researchers studying UBE2K, a key enzyme involved in the ubiquitination pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the UBE2K protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in the fields of molecular biology and cancer research.UBE2K, also known as Ubiquitin-conjugating enzyme E2 K, plays a crucial role in the ubiquitin-proteasome system, a process responsible for regulating protein degradation and turnover within cells.
Dysregulation of UBE2K has been implicated in various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions. By investigating the functions and mechanisms of UBE2K, researchers can gain insights that may lead to the development of novel treatment strategies for these conditions.
Product Name:
UBE2K Rabbit Polyclonal Antibody
SKU:
CAB1086
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UBE2K (NP_005330.1).
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
3093
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UBE2K antibody (CAB1086) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
