The UBE2J2 Polyclonal Antibody (CAB7316) is a valuable tool for researchers studying UBE2J2, a member of the ubiquitin-conjugating enzyme family. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the UBE2J2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in the fields of molecular biology and cell signaling.UBE2J2 is involved in protein degradation pathways by catalyzing the attachment of ubiquitin molecules to target proteins, marking them for degradation by the proteasome. Dysregulation of ubiquitination processes has been implicated in various diseases, including cancer and neurodegenerative disorders.
Therefore, understanding the function of UBE2J2 is crucial for developing targeted therapies and treatments for these conditions.By utilizing the UBE2J2 Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying protein degradation and identify potential therapeutic targets for disease intervention. This antibody serves as a reliable tool for studying the role of UBE2J2 in cellular processes and has the potential to advance our understanding of disease pathology and treatment strategies.
Product Name:
UBE2J2 Rabbit Polyclonal Antibody
SKU:
CAB7316
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human UBE2J2 (NP_477515.2).
Endoplasmic reticulum membrane, Single-pass type IV membrane protein.
Calculated MW:
29kDa
Observed MW:
29kDa
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
Purification Method:
Affinity purification
Gene ID:
118424
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UBE2J2 antibody (CAB7316) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
