The UBE2E1 Polyclonal Antibody is a valuable tool for researchers studying the UBE2E1 protein, which plays a key role in ubiquitin conjugation and protein degradation pathways. This antibody, raised in rabbits, exhibits high specificity and sensitivity in detecting UBE2E1 in human samples, making it ideal for use in Western blotting and immunohistochemistry applications.UBE2E1 is a crucial component of the ubiquitin-proteasome system, responsible for targeting proteins for degradation and regulating various cellular processes, including cell cycle progression, DNA repair, and protein quality control. Dysregulation of UBE2E1 has been implicated in various diseases, such as cancer, neurodegenerative disorders, and autoimmune conditions, making it a promising therapeutic target for drug development and disease intervention strategies.
By using the UBE2E1 Polyclonal Antibody, researchers can gain insights into the mechanisms underlying protein degradation pathways, as well as identify potential therapeutic targets and biomarkers for diseases associated with abnormal ubiquitin signaling. Its versatility and reliability make it a valuable tool for advancing our understanding of molecular pathways and developing novel treatments for a range of human ailments.
Product Name:
UBE2E1 Rabbit Polyclonal Antibody
SKU:
CAB13912
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-50 of human UBE2E1 (NP_003332.1).
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7324
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UBE2E1 Rabbit pAb (CAB13912) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
