The UBE2D3 Polyclonal Antibody (CAB14640) is a valuable tool for research involving UBE2D3, a member of the ubiquitin-conjugating enzyme family essential for protein degradation and regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the UBE2D3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in biochemistry and molecular biology.UBE2D3 is a key player in the ubiquitination pathway, facilitating the attachment of ubiquitin molecules to target proteins for degradation or regulation.
Its role in protein turnover and signaling pathways makes it a crucial component in cellular processes, with implications in various diseases including cancer, neurodegenerative disorders, and inflammatory conditions. Understanding the function of UBE2D3 is essential for advancing research and developing targeted therapies that modulate protein degradation mechanisms for therapeutic benefit.
Product Name:
UBE2D3 Rabbit Polyclonal Antibody
SKU:
CAB14640
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UBE2D3 (NP_003331.1).
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase.
Purification Method:
Affinity purification
Gene ID:
7323
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UBE2D3 Rabbit pAb (CAB14640) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
