The UBE2C Rabbit Monoclonal Antibody (CAB5206) is a versatile tool for researchers studying UBE2C, a key protein involved in the regulation of cell cycle progression and mitosis. This antibody, produced in rabbits, shows high specificity and reactivity towards human samples, making it an ideal choice for Western blot applications. By targeting the UBE2C protein, this antibody allows for the precise detection and analysis of UBE2C expression in various cell types, offering valuable insights into cell cycle regulation and potential therapeutic targets in cancer research.
UBE2C is a crucial player in the cell cycle machinery, promoting the degradation of cell cycle regulators and maintaining genomic stability. Dysregulation of UBE2C has been implicated in various cancers, making it a promising target for cancer treatment strategies. By studying the role of UBE2C using this antibody, researchers can uncover new pathways for potential drug development and targeted therapies aimed at disrupting cancer cell proliferation and survival.
Product Name:
UBE2C Rabbit Monoclonal Antibody
SKU:
CAB5206
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 70-150 of human UBE2C (O00762).
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19.
Purification Method:
Affinity purification
Gene ID:
11065
Clone Number:
ARC1166
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UBE2C Rabbit mAb (CAB5206) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
