The UBE2B Polyclonal Antibody (CAB6315) is a valuable tool for researchers studying UBE2B, a key protein involved in the ubiquitination process. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds specifically to the UBE2B protein, allowing for detection and analysis in a variety of cell types.UBE2B is essential for the proper function of the ubiquitin-proteasome system, which plays a crucial role in regulating protein degradation and turnover. Dysregulation of this system has been implicated in a variety of diseases, including cancer and neurodegenerative disorders.
By studying UBE2B, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.The UBE2B Polyclonal Antibody is a reliable tool for investigating the role of UBE2B in various biological processes and disease states. Its high specificity and sensitivity make it an ideal choice for research in the fields of molecular biology, cell biology, and biochemistry. Researchers interested in studying protein degradation pathways and their implications for human health will find this antibody particularly useful in their work.
Product Name:
UBE2B Rabbit Polyclonal Antibody
SKU:
CAB6315
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-152 of human UBE2B (NP_003328.1).
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
Purification Method:
Affinity purification
Gene ID:
7320
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UBE2B antibody (CAB6315) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
