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UBE2A/UBE2B Antibody (PACO01799)

SKU:
PACO01799
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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UBE2A/UBE2B Antibody (PACO01799)

The UBE2A/UBE2B Polyclonal Antibody (PAC01799) is a valuable tool for researchers studying the function of UBE2A and UBE2B proteins, essential components of the ubiquitination pathway. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it reliable for use in Western blot applications.UBE2A and UBE2B are key enzymes involved in the process of ubiquitination, a post-translational modification important for protein degradation, DNA repair, and cell signaling. By targeting these proteins, researchers can gain insights into their roles in various cellular processes, making this antibody essential for studies in cell biology, cancer research, and drug discovery.

With its ability to detect and analyze UBE2A and UBE2B in different cell types, the PAC01799 antibody is a versatile tool for investigating the mechanisms underlying protein degradation and regulation. By understanding the functions of UBE2A and UBE2B, researchers can explore potential therapeutic targets for diseases related to dysregulated ubiquitination pathways.

Antibody Name:UBE2A/UBE2B Antibody
Antibody SKU:PACO01799
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the C-terminal region of human UBE2A/B.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:UBE2A; RAD6A; Ubiquitin-conjugating enzyme E2 A; RAD6 homolog A; HR6A; hHR6A; Ubiquitin carrier protein A; Ubiquitin-protein ligase A; UBE2B; RAD6B; Ubiquitin-conjugating enzyme E2 B;
UniProt Protein Function:UBE2A: a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA.
UniProt Protein Details:

Protein type:EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase; Ligase

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: XY body; cytoplasm; nuclear chromatin; chromatin; cytosol

Molecular Function:protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of peptide antigen via MHC class I; protein autoubiquitination; protein polyubiquitination; maternal process involved in pregnancy; postreplication repair; in utero embryonic development; positive regulation of cell proliferation; DNA repair; histone H2A ubiquitination; response to UV

Disease: Mental Retardation, X-linked, Syndromic, Nascimento Type

UniProt Code:P49459
NCBI GenInfo Identifier:33518639
NCBI Gene ID:7319
NCBI Accession:P49459.2
Molecular Weight:
NCBI Full Name:Ubiquitin-conjugating enzyme E2 A
UniProt Protein Name:Ubiquitin-conjugating enzyme E2 A
UniProt Synonym Protein Names:RAD6 homolog A; HR6A; hHR6A; Ubiquitin carrier protein A; Ubiquitin-protein ligase A
Protein Family:Ubiquitin-conjugating enzyme
UniProt Gene Name:UBE2A  
UniProt Entry Name:UBE2A_HUMAN

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