The UBAH3A Polyclonal Antibody (PACO55042) offered by Assay Genie is a valuable tool for research involving UBAH3A, a protein involved in various cellular processes. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to UBAH3A, this antibody allows for the detection and analysis of UBAH3A protein in different cell types, making it ideal for studies in cell biology and cancer research.UBAH3A is known to play a role in regulating cellular functions such as protein trafficking and membrane dynamics. Its involvement in these processes makes it a key target for research into cellular signaling pathways and disease mechanisms.
By understanding the function of UBAH3A, researchers can gain insights into its impact on cellular behavior and potentially develop targeted therapies for diseases related to dysregulation of UBAH3A activity.Overall, the UBAH3A Polyclonal Antibody from Assay Genie provides researchers with a reliable tool for investigating the function of UBAH3A in cellular processes and disease states. Its high reactivity and specificity make it a valuable asset for studies aiming to elucidate the role of UBAH3A in various biological contexts.
Immunofluorescent analysis of HepG2 cells using PACO55042 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Western Blot. Positive WB detected in: K562 whole cell lysate, HL60 whole cell lysate, Hela whole cell lysate, Rat heart tissue. All lanes: UBASH3A antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 75, 70, 60 kDa. Observed band size: 70 kDa.
Background:
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
Synonyms:
Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1), UBASH3A, STS2
UniProt Protein Function:
STS2: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Protein phosphatase, tyrosine (non-receptor)Chromosomal Location of Human Ortholog: 21q22.3Cellular Component: cytosolMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
