The UBASH3A Polyclonal Antibody (PAC013656) is a powerful tool for researchers studying UBASH3A, a key protein involved in immune regulation and signaling pathways. This antibody, generated in rabbits, shows high specificity and sensitivity for UBASH3A in human samples, making it ideal for a range of experimental techniques including Western blotting.UBASH3A, also known as T-cell ubiquitin ligand 2 (TULA-2), plays a critical role in regulating immune cell activation and function. By targeting UBASH3A, researchers can gain insights into the mechanisms underlying immune responses and potential therapeutic interventions for immune-related disorders such as autoimmune diseases and inflammation.
With its ability to detect UBASH3A in various cell types, this antibody is essential for studies investigating the role of UBASH3A in immunology, cancer, and other disease states. By understanding the function of UBASH3A, researchers can pave the way for the development of novel treatments and interventions to modulate immune responses effectively.
ubiquitin associated and SH3 domain containing, A;UBASH3A;CLIP4;STS-2;TULA ;
UniProt Protein Function:
STS2: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Protein phosphatase, tyrosine (non-receptor)Chromosomal Location of Human Ortholog: 21q22.3Cellular Component: cytosolMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
