The UBA SH3-containing protein 3A Polyclonal Antibody (PACO04601) is a valuable tool for researchers studying UBA SH3-containing protein 3A (UBASH3A), a key player in various cellular processes. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications.UBASH3A is known to be involved in immune regulation, signal transduction, and cell proliferation, making it a promising target for studies in immunology and cancer research. By specifically binding to UBASH3A protein, this antibody enables researchers to detect and analyze UBASH3A expression in different cell types, providing valuable insights into its function and potential therapeutic applications.
With its importance in immune response modulation and its implications in diseases like cancer and autoimmune disorders, understanding the role of UBASH3A is crucial for the development of targeted therapies. The UBA SH3-containing protein 3A Polyclonal Antibody is a reliable tool for investigating the function and regulation of UBASH3A in various research contexts.
Antibody Name:
UBASH3A Antibody
Antibody SKU:
PACO04601
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human TULA.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
UBASH3A; STS2; Ubiquitin-associated and SH3 domain-containing protein A; Cbl-interacting protein 4; CLIP4; Suppressor of T-cell receptor signaling 2; STS-2; T-cell ubiquitin ligand 1; TULA-1
UniProt Protein Function:
STS2: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Protein phosphatase, tyrosine (non-receptor)Chromosomal Location of Human Ortholog: 21q22.3Cellular Component: cytosolMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
