The UBA2 Polyclonal Antibody (CAB17342) is a valuable tool for researchers studying UBA2, a protein involved in the process of SUMOylation, a post-translational modification that regulates various cellular functions. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications.UBA2 plays a crucial role in the SUMOylation pathway, which is essential for the regulation of gene expression, protein stability, and DNA repair. Dysregulation of SUMOylation has been linked to various diseases, including cancer, neurodegenerative disorders, and viral infections.
The UBA2 Polyclonal Antibody enables the detection and analysis of UBA2 levels in different cell types, offering insights into its function and potential as a therapeutic target in disease research.By understanding the role of UBA2 in cellular processes, researchers can shed light on its biological functions and explore its implications for disease pathogenesis. The UBA2 Polyclonal Antibody provides a reliable tool for studying UBA2 in the context of SUMOylation and its impact on health and disease.
Product Name:
UBA2 Rabbit Polyclonal Antibody
SKU:
CAB17342
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 60-160 of human UBA2 (NP_005490.1).
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).
Purification Method:
Affinity purification
Gene ID:
10054
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung, using UBA2 Rabbit pAb (CAB17342) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
