The UBA1 Polyclonal Antibody (CAB12359) is a valuable tool for researchers studying the UBA1 protein, a critical component in the process of ubiquitination. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the UBA1 protein, this antibody enables the detection and analysis of UBA1 in various cell types, making it an essential reagent for studies in molecular biology and cellular signaling pathways.UBA1 is a key enzyme involved in the ubiquitin-proteasome system, playing a crucial role in protein degradation and cellular regulation.
Dysregulation of UBA1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. By understanding the function and activity of UBA1, researchers can uncover potential therapeutic targets for the treatment of these diseases and further elucidate the mechanisms underlying protein turnover and cell signaling processes.
Product Name:
UBA1 Rabbit Polyclonal Antibody
SKU:
CAB12359
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human UBA1 (NP_695012.1).
The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described.
Purification Method:
Affinity purification
Gene ID:
7317
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UBA1 Rabbit pAb (CAB12359) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
