The UACA Polyclonal Antibody (CAB9713) is a key tool for researchers studying UACA, a pivotal gene involved in DNA repair processes and cell cycle regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting UACA in human samples, making it ideal for use in Western blotting and immunohistochemistry applications.UACA is known for its essential role in maintaining genomic stability and preventing the accumulation of DNA damage.
Dysregulation of UACA has been linked to various diseases, including cancer and neurological disorders, highlighting its potential as a therapeutic target. By using the UACA Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of UACA, helping to advance our understanding of disease mechanisms and guide the development of targeted therapies.
Product Name:
UACA Rabbit Polyclonal Antibody
SKU:
CAB9713
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human UACA (NP_060473.2).
Sequence:
MKSL KSRL RRQD VPGP ASSG AAAA SAHA ADWN KYDD RLMK AAER GDVE KVTS ILAK KGVN PGKL DVEG RSVF HVVT SKGN LECL NAIL IH
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
NUCLING; UACA
Positive Sample:
U-87MG,293T,HT-1080,SKOV3
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus, cytoskeleton.
Calculated MW:
163kDa
Observed MW:
162kDa
This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. This protein has also been proposed to negatively regulate apoptosis based on experiments in human cell lines in which the protein was shown to interact with PRKC apoptosis WT1 regulator protein, also known as PAR-4, and inhibit translocation of the PAR-4 receptor. Autoantibodies to this protein have been identified in human patients with panuveitis and Graves' disease. Differential expression of this gene has been observed in various human cancers.
Purification Method:
Affinity purification
Gene ID:
55075
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UACA antibody (CAB9713) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
