The Tyrosine Hydroxylase Rabbit Monoclonal Antibody (CAB5079) is a valuable tool for researchers studying tyrosine hydroxylase, an enzyme involved in the synthesis of catecholamines like dopamine and norepinephrine. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to tyrosine hydroxylase, this antibody enables precise detection and analysis of the enzyme in various cell types.Tyrosine hydroxylase plays a crucial role in the biosynthesis of neurotransmitters, making it a key target for research in neurology, psychiatry, and endocrinology. Dysregulation of tyrosine hydroxylase activity has been implicated in a variety of neurological disorders, including Parkinson's disease, schizophrenia, and depression.
Therefore, understanding the expression and function of tyrosine hydroxylase is essential for unraveling the mechanisms underlying these conditions and developing targeted therapies.Researchers investigating the role of tyrosine hydroxylase in neurotransmitter production, neuronal function, and neurodegenerative diseases can benefit from the specificity and reliability of the Tyrosine Hydroxylase Rabbit Monoclonal Antibody (CAB5079). Its ability to selectively detect tyrosine hydroxylase in human samples makes it a valuable tool for advancing our understanding of catecholamine biosynthesis and its implications for human health
Product Name:
Tyrosine Hydroxylase Rabbit Monoclonal Antibody
SKU:
CAB5079
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Tyrosine Hydroxylase (P07101).
axon, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytosol, dendrite, mitochondrion, neuron projection, nucleus, perikaryon, perinuclear region of cytoplasm, smooth endoplasmic reticulum, synaptic vesicle, terminal bouton
Calculated MW:
59kDa
Observed MW:
59kDa
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
7054
Clone Number:
ARC1184
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Tyrosine Hydroxylase Rabbit mAb (CAB5079) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
