The Tyrosine Hydroxylase Polyclonal Antibody (CAB0028) is a valuable tool for researchers studying tyrosine hydroxylase, a critical enzyme involved in the synthesis of neurotransmitters such as dopamine, norepinephrine, and epinephrine. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications.Tyrosine hydroxylase is essential for the production of catecholamines, neurotransmitters that play key roles in regulating mood, behavior, and stress responses. Dysregulation of tyrosine hydroxylase activity has been implicated in various neurological and psychiatric disorders, making it a target of interest for research in neuroscience and pharmacology.
By detecting and binding to tyrosine hydroxylase protein, this polyclonal antibody enables researchers to study the expression and activity of this enzyme in different cell types and tissues. This antibody is a valuable tool for investigating the role of tyrosine hydroxylase in neurological disorders, drug addiction, and neurodegenerative diseases, providing insights that may lead to the development of novel therapeutic strategies.
Product Name:
Tyrosine Hydroxylase Rabbit Polyclonal Antibody
SKU:
CAB0028
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synTyrosine Hydroxylase etic peptide corresponding to a sequence wiTyrosine Hydroxylase in amino acids 411-528 of human Tyrosine Hydroxylase (NP_954986.2).
axon, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytosol, dendrite, mitochondrion, neuron projection, nucleus, perikaryon, perinuclear region of cytoplasm, smooth endoplasmic reticulum, synaptic vesicle, terminal bouton
Calculated MW:
59kDa
Observed MW:
59kDa/58kDa
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
7054
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells using Tyrosine Hydroxylase Rabbit pAb(CAB0028) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
