TYR Rabbit Polyclonal Antibody (CAB1254)
- SKU:
- CAB1254
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | TYR Rabbit Polyclonal Antibody |
SKU: | CAB1254 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 20-340 of human Tyrosinase (NP_000363.1). |
Sequence: | PWSG DRSP CGQL SGRG SCQN ILLS NAPL GPQF PFTG VDDR ESWP SVFY NRTC QCSG NFMG FNCG NCKF GFWG PNCT ERRL LVRR NIFD LSAP EKDK FFAY LTLA KHTI SSDY VIPI GTYG QMKN GSTP MFND INIY DLFV WMHY YVSM DALL GGSE IWRD IDFA HEAP AFLP WHRL FLLR WEQE IQKL TGDE NFTI PYWD WRDA EKCD ICTD EYMG GQHP TNPN LLSP ASFF SSWQ IVCS RLEE YNSH QSLC NGTP EGPL RRNP GNHD KSRT PRLP SSAD VEFC LSLT QYES GSMD KAAN FSFR NTLE GFAS PLTG IADA S |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3; Tyrosinase |
Positive Sample: | Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Melanosome membrane, Single-pass type I membrane protein. |
Calculated MW: | 60kDa |
Observed MW: | 80kDa |
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.
Purification Method: | Affinity purification |
Gene ID: | 7299 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |