The Tyrosinase Polyclonal Antibody (CAB11988) is a valuable tool for researchers studying tyrosinase, an enzyme involved in the production of melanin in the skin and eyes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the tyrosinase protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for research in dermatology, ophthalmology, and melanoma studies.
Tyrosinase is a critical enzyme in the melanin biosynthesis pathway and plays a significant role in determining skin and eye pigmentation. Abnormalities in tyrosinase activity have been implicated in conditions such as albinism and various forms of skin cancer, making it a crucial target for research into these diseases. Understanding the function and regulation of tyrosinase can provide valuable insights for developing treatments and interventions in dermatology and oncology.
Product Name:
Tyrosinase Polyclonal Antibody
SKU:
CAB11988
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-455 of human Tyrosinase (NP_000363.1).
Melanosome membrane, Single-pass type I membrane protein.
Calculated MW:
60kDa
Observed MW:
Refer to figures
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.
Purification Method:
Affinity purification
Gene ID:
7299
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of Tyrosinase in paraffin-embedded Human malignant melanoma tissue using Tyrosinase Rabbit pAb (CAB11988) at a dilution of 1:2000 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Buffer(pH 6.0) prior to IHC staining.
