TYR Rabbit Polyclonal Antibody (CAB13608)
- SKU:
- CAB13608
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | TYR Rabbit Polyclonal Antibody |
SKU: | CAB13608 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-340 of human Tyrosinase (NP_000363.1). |
Sequence: | FPRA CVSS KNLM EKEC CPPW SGDR SPCG QLSG RGSC QNIL LSNA PLGP QFPF TGVD DRES WPSV FYNR TCQC SGNF MGFN CGNC KFGF WGPN CTER RLLV RRNI FDLS APEK DKFF AYLT LAKH TISS DYVI PIGT YGQM KNGS TPMF NDIN IYDL FVWM HYYV SMDA LLGG SEIW RDID FAHE APAF LPWH RLFL LRWE QEIQ KLTG DENF TIPY WDWR DAEK CDIC TDEY MGGQ HPTN PNLL SPAS FFSS WQIV CSRL EEYN SHQS LCNG TPEG PLRR NPGN HDKS RTPR LPSS ADVE FCLS LTQY ESGS MDKA ANFS F |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3; Tyrosinase |
Positive Sample: | Rat skin |
Conjugate: | Unconjugated |
Cellular Localization: | Melanosome membrane, Single-pass type I membrane protein. |
Calculated MW: | 60kDa |
Observed MW: | 80kDa |
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.
Purification Method: | Affinity purification |
Gene ID: | 7299 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |