TYMS Rabbit Polyclonal Antibody (CAB10441)
- SKU:
- CAB10441
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | TYMS Rabbit Polyclonal Antibody |
SKU: | CAB10441 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human TYMS (NP_001062.1). |
Sequence: | MPVA GSEL PRRP LPPA AQER DAEP RPPH GELQ YLGQ IQHI LRCG VRKD DRTG TGTL SVFG MQAR YSLR DEFP LLTT KRVF WKGV LEEL LWFI KGST NAKE LSSK GVKI WDAN GSRD FLDS LGFS TREE GDLG PVYG FQWR HFGA EYRD MESD YSGQ GVDQ LQRV IDTI KTNP DDRR IIMC AWNP RDLP LMAL PPCH ALCQ FYVV NSEL SCQL YQRS GDMG LGVP FNIA SYAL LTYM IAHI TGLK PGDF IHTL GDAH IYLN HIEP LKIQ LQRE PRPF PKLR ILRK VEKI DDFK AEDF QIEG YNPH PTIK MEMA V |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | TS; TMS; DKCD; HST422; TYMS |
Positive Sample: | MOLT-4,HeLa,293F,T-47D |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Mitochondrion, Mitochondrion inner membrane, Mitochondrion matrix, Nucleus. |
Calculated MW: | 36kDa |
Observed MW: | 36kDa |
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy.
Purification Method: | Affinity purification |
Gene ID: | 7298 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |