Thioredoxin reductase 2 (TXNRD2 ) Rabbit Monoclonal Antibody (CAB8884)
- SKU:
- CAB8884
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | Thioredoxin reductase 2 (TXNRD2 ) Rabbit Monoclonal Antibody |
SKU: | CAB8884 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Thioredoxin reductase 2 (TXNRD2 ) (NP_006431.2). |
Sequence: | MAAM AVAL RGLG GRFR WRTQ AVAG GVRG AARG AAAG QRDY DLLV VGGG SGGL ACAK EAAQ LGRK VAVV DYVE PSPQ GTRW GLGG TCVN VGCI PKKL MHQA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | TR; TR3; SELZ; GCCD5; TRXR2; TR-BETA; Thioredoxin reductase 2 (TXNRD2 ) |
Positive Sample: | HeLa,293T,Mouse liver,Mouse spleen,Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion |
Calculated MW: | 57kDa |
Observed MW: | 57kDa |
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 10587 |
Clone Number: | ARC1339 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |