Thioredoxin reductase 1 (TXNRD1 ) Rabbit Monoclonal Antibody (CAB4725)
- SKU:
- CAB4725
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | Thioredoxin reductase 1 (TXNRD1 ) Rabbit Monoclonal Antibody |
SKU: | CAB4725 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-649 of human Thioredoxin reductase 1 (TXNRD1 ) (Q16881). |
Sequence: | MGCA EGKA VAAA APTE LQTK GKNG DGRR RSAK DHHP GKTL PENP AGFT STAT ADSR ALLQ AYID GHSV VIFS RSTC TRCT EVKK LFKS LCVP YFVL ELDQ TEDG RALE GTLS ELAA ETDL PVVF VKQR KIGG HGPT LKAY QEGR LQKL LKMN GPED LPKS YDYD LIII GGGS GGLA AAKE AAQY GKKV MVLD FVTP TPLG TRWG LGGT CVNV GCIP KKLM HQAA LLGQ ALQD SRNY GWKV EETV KHDW DRMI EAVQ NHIG SLNW GYRV ALRE KKVV YENA YGQF IGPH RIKA TNNK GKEK IYSA ERFL IATG ERPR YLGI PGDK EYCI SSDD LFSL PYCP GKTL VVGA SYVA LECA GFLA GIGL DVTV MVRS ILLR GFDQ DMAN KIGE HMEE HGIK FIRQ FVPI KVEQ IEAG TPGR LRVV AQST NSEE IIEG EYNT VMLA IGRD ACTR KIGL ETVG VKIN EKTG KIPV TDEE QTNV PYIY AIGD ILED KVEL TPVA IQAG RLLA QRLY AGST VKCD YENV PTTV FTPL EYGA CGLS EEKA VEKF GEEN IEVY HSYF WPLE WTIP SRDN NKCY AKII CNTK DNER VVGF HVLG PNAG EVTQ GFAA ALKC GLTK KQLD STIG IHPV CAEV FTTL SVTK RSGA SILQ AGCU G |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | TR; TR1; TXNR; TRXR1; GRIM-12; Thioredoxin reductase 1 (TXNRD1 ) |
Positive Sample: | HeLa,A-549,MCF7,Jurkat,Mouse brain,Mouse heart,Mouse thymus,Rat liver,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus |
Calculated MW: | 71kDa |
Observed MW: | 60kDa, 71kDa |
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis.
Purification Method: | Affinity purification |
Gene ID: | 7296 |
Clone Number: | ARC1106 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |