Similarly, the TXNRD1 Rabbit Monoclonal Antibody (CAB4725) is a vital tool for researchers investigating the thioredoxin reductase 1 (TXNRD1) protein, which plays a key role in redox regulation and antioxidant defense mechanisms within cells. The antibody, developed in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications.TXNRD1 is a crucial enzyme involved in maintaining cellular redox balance and protecting cells from oxidative stress. Dysregulation of TXNRD1 has been linked to various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
By using the TXNRD1 Rabbit Monoclonal Antibody, researchers can accurately detect and study TXNRD1 expression in different cell types, providing valuable insights into the mechanisms underlying these diseases.Overall, the TXNRD1 Rabbit Monoclonal Antibody is a valuable tool for researchers interested in exploring the role of TXNRD1 in cellular redox signaling and its implications in disease pathogenesis. Its high reactivity and specificity make it an essential component for studies in biochemistry, molecular biology, and medical research.
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis.
Purification Method:
Affinity purification
Gene ID:
7296
Clone Number:
ARC1106
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Thioredoxin reductase 1 (Thioredoxin reductase 1 (TXNRD1 ) ) Rabbit mAb (CAB4725) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
