Thioredoxin reductase 1 (TXNRD1 ) Rabbit Polyclonal Antibody (CAB16631)
- SKU:
- CAB16631
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | Thioredoxin reductase 1 (TXNRD1 ) Rabbit Polyclonal Antibody |
SKU: | CAB16631 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 410-490 of human Thioredoxin reductase 1 (TXNRD1) (NP_001087240.1). |
Sequence: | EAGT PGRL RVVA QSTN SEEI IEGE YNTV MLAI GRDA CTRK IGLE TVGV KINE KTGK IPVT DEEQ TNVP YIYA IGDI LEDK V |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:200 |
Synonyms: | TR; TR1; TXNR; TRXR1; GRIM-12; Thioredoxin reductase 1 (TXNRD1 ) |
Positive Sample: | HepG2,BxPC-3,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, extracellular exosome, fibrillar center, mitochondrion, nucleoplasm |
Calculated MW: | 71kDa |
Observed MW: | 65kDa |
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis.
Purification Method: | Affinity purification |
Gene ID: | 7296 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |