The TXNIP Polyclonal Antibody (CAB9342) is a valuable tool for researchers studying thioredoxin-interacting protein (TXNIP), a key player in cellular redox homeostasis and metabolism. This rabbit-derived antibody offers highly specific and sensitive detection of TXNIP in human samples, making it ideal for Western blot applications. By targeting the TXNIP protein, researchers can gain insights into its role in regulating glucose metabolism, apoptosis, and oxidative stress pathways in various cell types.TXNIP, also known as Vitamin D3 up-regulated protein 1 (VDUP1), is involved in multiple cellular processes, including glucose uptake and insulin sensitivity, making it a potential therapeutic target for metabolic disorders such as diabetes and obesity.
Additionally, TXNIP has been linked to the pathogenesis of various diseases, including cancer, cardiovascular diseases, and neurodegenerative disorders, highlighting its importance in biomedical research.By utilizing the TXNIP Polyclonal Antibody (CAB9342), researchers can further explore the molecular mechanisms underlying TXNIP's functions and potential implications in disease pathology. This antibody's high specificity and reliability make it an essential tool for investigating TXNIP-related pathways and developing targeted therapies for a range of diseases and conditions.
Product Name:
TXNIP Rabbit Polyclonal Antibody
SKU:
CAB9342
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-166 of human TXNIP (NP_006463.3).
This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10628
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse thymus, using TXNIP Rabbit pAb (CAB9342) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
