The TXNIP Polyclonal Antibody (PAC037578) is a valuable tool for researchers studying TXNIP, a critical regulator of cellular redox balance and glucose metabolism. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for various experimental applications, including Western blot analysis.TXNIP, also known as thioredoxin-interacting protein, is a key player in cellular stress responses and metabolic pathways. Dysregulation of TXNIP has been implicated in various diseases, including cancer, diabetes, and cardiovascular disorders.
By targeting TXNIP, researchers can gain insights into the mechanisms underlying these conditions and potentially identify novel therapeutic strategies.This polyclonal antibody recognizes TXNIP protein in different cell types, allowing for detailed analysis and characterization in various research settings. Its reliability and specificity make it an essential tool for investigations into the role of TXNIP in health and disease. Unlocking the functions of TXNIP may lead to the development of new treatments and interventions for a range of pathological conditions.
Antibody Name:
Txnip Antibody (PACO37578)
Antibody SKU:
PACO37578
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse Thioredoxin-interacting protein (1-397AA)
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.
Synonyms:
Thioredoxin-interacting protein (Vitamin D3 up-regulated protein 1), Txnip, Vdup1
UniProt Protein Function:
TXNIP: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Belongs to the arrestin family.Protein type: Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Tumor suppressorChromosomal Location of Human Ortholog: 3 F2.1|3 41.93 cMCellular Component: cytoplasm; mitochondrial intermembrane space; nucleusMolecular Function: enzyme inhibitor activity; protein binding; ubiquitin protein ligase bindingBiological Process: cell cycle; keratinocyte differentiation; negative regulation of cell division; negative regulation of transcription from RNA polymerase II promoter; platelet-derived growth factor receptor signaling pathway; positive regulation of apoptosis; protein import into nucleus; regulation of cell proliferation; regulation of transcription, DNA-templated; response to oxidative stress; transcription, DNA-dependent
