TXNIP Antibody (PACO20800)
- SKU:
- PACO20800
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
TXNIP Antibody (PACO20800)
The TXNIP Polyclonal Antibody (PAC020800) is a valuable tool for researchers studying TXNIP, a protein involved in the regulation of cellular redox balance and metabolism. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TXNIP protein, this antibody facilitates the detection and analysis of TXNIP expression in various cell types, making it ideal for investigations in the fields of metabolism, diabetes, and cancer research.
TXNIP, also known as thioredoxin-interacting protein, is a key regulator of cellular oxidative stress and glucose metabolism. Its involvement in these pathways positions it as a potential target for therapeutic interventions in diseases such as diabetes, cardiovascular disorders, and cancer. Research into the functions of TXNIP is essential for uncovering new treatment strategies that target redox signaling and metabolic dysregulation in these conditions.
| Antibody Name: | TXNIP Antibody (PACO20800) |
| Antibody SKU: | PACO20800 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:30-1:150 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human TXNIP |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20800(TXNIP Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). |
| Synonyms: | thioredoxin interacting protein |
| UniProt Protein Function: | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). |
| NCBI Summary: | This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q9H3M7 |
| NCBI GenInfo Identifier: | 928192549 |
| NCBI Gene ID: | 10628 |
| NCBI Accession: | NP_001300901.1 |
| UniProt Secondary Accession: | Q9H3M7,Q16226, Q6PML0, Q9BXG9, B4E3D3, |
| UniProt Related Accession: | Q9H3M7 |
| Molecular Weight: | 37,319 Da |
| NCBI Full Name: | thioredoxin-interacting protein isoform 2 |
| NCBI Synonym Full Names: | thioredoxin interacting protein |
| NCBI Official Symbol: | TXNIPÂ Â |
| NCBI Official Synonym Symbols: | THIF; VDUP1; ARRDC6; HHCPA78; EST01027Â Â |
| NCBI Protein Information: | thioredoxin-interacting protein |
| UniProt Protein Name: | Thioredoxin-interacting protein |
| UniProt Synonym Protein Names: | Thioredoxin-binding protein 2; Vitamin D3 up-regulated protein 1 |
| Protein Family: | TATA-binding protein |
| UniProt Gene Name: | TXNIPÂ Â |
| Antibodies | ELISA Kits |
| Anti-TXNIP Antibody (CAB9342) | Human TXNIP / Thioredoxin-interacting protein ELISA Kit |
| Human Thioredoxin-interacting protein (TXNIP) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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