The TXNDC5 Polyclonal Antibody (CAB14152) is a valuable tool for researchers studying TXNDC5, a protein involved in redox regulation and cellular stress responses. This antibody, produced in rabbits, is highly specific for detecting TXNDC5 in human samples and has been validated for use in Western blot applications. By binding to TXNDC5, this antibody allows for the visualization and analysis of the protein in various cell types, making it ideal for studies in oxidative stress, cellular signaling, and disease mechanisms.TXNDC5, also known as thioredoxin domain-containing protein 5, plays a critical role in maintaining cellular redox balance and protecting cells from oxidative damage. Dysregulation of TXNDC5 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular disease.
By studying the function of TXNDC5, researchers can gain insights into the mechanisms underlying these pathologies and potentially identify new therapeutic strategies for treating them.Overall, the TXNDC5 Polyclonal Antibody (CAB14152) is a valuable tool for researchers interested in exploring the role of TXNDC5 in cellular homeostasis, oxidative stress responses, and disease development. Its high specificity and sensitivity make it a reliable choice for studies aiming to elucidate the biological functions of TXNDC5 and its potential as a therapeutic target.
Product Name:
TXNDC5 Rabbit Polyclonal Antibody
SKU:
CAB14152
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-324 of human TXNDC5 (NP_001139021.1).
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene.
Purification Method:
Affinity purification
Gene ID:
81567
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using TXNDC5 Rabbit pAb (CAB14152) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
