The Twist2 Polyclonal Antibody (CAB5599) is a valuable tool for research involving Twist2, a transcription factor that plays a critical role in cell differentiation and development. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for studies in molecular biology and cancer research.Twist2 is known for its involvement in epithelial-mesenchymal transition (EMT), a crucial process in embryonic development and tumor metastasis. By targeting Twist2, researchers can gain insights into the mechanisms underlying these processes and potential therapeutic targets for cancer treatment.
This antibody is validated for use in various applications, including Western blot analysis and immunohistochemistry, allowing for detailed examination of Twist2 expression in different cell types and tissues. Its specificity and sensitivity make it a valuable tool for investigating the role of Twist2 in both normal development and disease states.
Product Name:
TWIST2 Rabbit Polyclonal Antibody
SKU:
CAB5599
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TWIST2 (NP_476527.1).
The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found.
Purification Method:
Affinity purification
Gene ID:
117581
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat uterus, using TWIST2 antibody (CAB5599) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
