p63 Rabbit Polyclonal Antibody (CAB2137)
- SKU:
- CAB2137
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | p63 Rabbit Polyclonal Antibody |
SKU: | CAB2137 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 166-362 of human p63 (NP_001108452.1). |
Sequence: | PPSH LIRV EGNS HAQY VEDP ITGR QSVL VPYE PPQV GTEF TTVL YNFM CNSS CVGG MNRR PILI IVTL ETRD GQVL GRRC FEAR ICAC PGRD RKAD EDSI RKQQ VSDS TKNG DGTK RPFR QNTH GIQM TSIK KRRS PDDE LLYL PVRG RETY EMLL KIKE SLEL MQYL PQHT IETY RQQQ QQQH QHLL QKQT SIQS P |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B) |
Positive Sample: | A-431,mouse skin,rat skin |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 77kDa |
Observed MW: | 75kDa |
This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.
Purification Method: | Affinity purification |
Gene ID: | 8626 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |