The Tumor Protein 63 Polyclonal Antibody (CAB2137) is a valuable tool for researchers studying the tumor protein 63 (TP63), a protein involved in cell growth regulation and development. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.TP63, a member of the p53 tumor suppressor gene family, plays a critical role in various cellular processes, including cell cycle regulation, apoptosis, and differentiation. Dysregulation of TP63 has been implicated in a wide range of cancers, making it a promising target for cancer research and therapy development.
By specifically binding to the TP63 protein, this polyclonal antibody enables researchers to detect and analyze TP63 expression in different cell types, providing valuable insights into its role in cancer development and progression. With its versatility and reliability, the Tumor Protein 63 Polyclonal Antibody is an essential tool for studies in oncology and molecular biology.
Product Name:
p63 Rabbit Polyclonal Antibody
SKU:
CAB2137
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 166-362 of human p63 (NP_001108452.1).
This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.
Purification Method:
Affinity purification
Gene ID:
8626
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using p63 Rabbit pAb (CAB2137) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Negative control (NC):MCF7Exposure time: 10s.
