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Tumor Necrosis Factor-a monoclonal antibody (PE) (AGIM0381)

SKU:
AGIM0381
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2b
Clone:
IT-5H2
Conjugation:
PE
Applications:
FC
€199
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Description

system_update_altDatasheet
Product Name:Tumor Necrosis Factor-a monoclonal antibody (PE)
Product Code:AGIM0381
Size:100 µL
Reactivity:Human
Clone:IT-5H2
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG2b
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P24043
Background:TNF-alpha is a cytokine produced by monocytes, macrophages, neutrophils, NK cells, CD4+ T cells and many transformed cells. It can be expressed as a 17 kDa free molecule, or as a 26 kDa membrane protein. TNF-alpha easily forms stable trimers, but also other multimeric complexes. In the immune system, it is an important regulator, which has cytolytic and cytostatic activity against a range of tumor cells, increases fibroblast proliferation and supports neutrophil chemotaxis and phagocytosis.
UniProt Protein Function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
UniProt Protein Details:
NCBI Summary:Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P24043
NCBI GenInfo Identifier:28559088
NCBI Gene ID:3908
NCBI Accession:NP_000417.2
UniProt Secondary Accession:P24043,Q14736, Q5VUM2, Q93022
UniProt Related Accession:P24043
Molecular Weight:
NCBI Full Name:laminin subunit alpha-2 isoform a
NCBI Synonym Full Names:laminin subunit alpha 2
NCBI Official Symbol:LAMA2  
NCBI Official Synonym Symbols:LAMM  
NCBI Protein Information:laminin subunit alpha-2
UniProt Protein Name:Laminin subunit alpha-2
UniProt Synonym Protein Names:Laminin M chain; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; Merosin heavy chain
Protein Family:Laminin
UniProt Gene Name:LAMA2  
UniProt Entry Name:

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