The TULP3 Polyclonal Antibody (PACO30900) is a valuable tool for researchers studying TULP3, a protein involved in intracellular transport and signaling pathways. This antibody, raised in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By targeting the TULP3 protein, this antibody allows for the detection and analysis of TULP3 expression in various cell types, making it an essential tool for studies in cell biology and signal transduction research.TULP3, also known as tubby-like protein 3, is known to play a crucial role in the transport of membrane proteins within cells and is involved in processes such as endocytosis and vesicle trafficking.
Understanding the function of TULP3 is important for unraveling its role in cellular signaling pathways and its potential implications in diseases such as cancer and neurological disorders. By using the TULP3 Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying TULP3-mediated cellular processes and its impact on disease pathology.
Antibody Name:
TULP3 Antibody (PACO30900)
Antibody SKU:
PACO30900
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Tubby-related protein 3 protein (1-260AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO30900 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO30900 at dilution of 1:100.
Background:
Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis.
Synonyms:
Tubby-related protein 3 (Tubby-like protein 3), TULP3, TUBL3
UniProt Protein Function:
TULP3: Negatively regulates SHH signal transduction. Probably functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to phosphorylated inositide lipids. Belongs to the TUB family.Chromosomal Location of Human Ortholog: 12p13.3Cellular Component: cilium; nucleolus; nucleus; plasma membraneMolecular Function: enzyme binding; phosphoinositide binding; protein binding; protein complex bindingBiological Process: negative regulation of smoothened signaling pathway; regulation of G-protein coupled receptor protein signaling pathway
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2009]
